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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2021
or
    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from ___________________ to ___________________
Commission File Number: 001-39263
Zentalis Pharmaceuticals, Inc.
(Exact name of registrant as specified in its charter)
Delaware82-3607803
(State or other jurisdiction of
incorporation or organization)
(I.R.S. Employer
Identification No.)
530 Seventh Avenue,
Suite 2201
New York,
 New York
10018
(Address of principal executive offices)(Zip Code)
(212) 433-3791
(Registrant’s telephone number, including area code)
N/A
(Former name, former address and former fiscal year, if changed since last report)
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common Stock,
$0.001 par value per share
ZNTLThe Nasdaq Global Market
Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.     Yes ☒  No ☐   
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  ☒    No  ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer  Accelerated filer
Non-accelerated Filer
  Smaller reporting company
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. 
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes      No  ☒
As of August 6, 2021, the registrant had 45,052,904 shares of common stock, $0.001 par value per share, outstanding.


Table of Contents
Page
PART I.
Item 1.
Item 2.
Item 3.
Item 4.
PART II.
Item 1.
Item 1A.
Item 2.
Item 3.
Item 4.
Item 5.
Item 6.
i


CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. All statements other than statements of historical facts contained in this Quarterly Report are forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. All statements other than statements of historical fact contained in this Quarterly Report, including without limitation statements regarding our future results of operations and financial position, the anticipated impact of the COVID-19 pandemic on our business, the sufficiency of our cash and cash equivalents to fund our operations, business strategy, prospective products and product candidates, clinical trial timelines and expected timing for the release of data, research and development costs, future revenue, timing and likelihood of success, activities under our existing collaborations and potential collaboration opportunities, and plans and objectives of management are forward-looking statements.

The forward-looking statements in this Quarterly Report are only predictions and are based largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition and results of operations. These forward-looking statements speak only as of the date of this Quarterly Report and are subject to a number of known and unknown risks, uncertainties, assumptions and other important factors, including those described under “Summary Risk Factors” below and in the sections in this Quarterly Report entitled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere in this Quarterly Report.
Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond our control, you should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in an evolving environment. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.
SUMMARY RISK FACTORS

Our business is subject to numerous risk and uncertainties, including those described in Part II, Item 1A. “Risk Factors” in this Quarterly Report on Form 10-Q. You should carefully consider these risk and uncertainties when investing in our common stock. These principal risks and uncertainties affecting our business include the following:

•We have a limited operating history, have not completed any clinical trials and have no products approved for commercial sale, which may make it difficult for you to evaluate our current business and predict our future success and viability.

•We have incurred significant net losses since inception and we expect to continue to incur significant net losses for the foreseeable future.

•We will require substantial additional capital to finance our operations. If we are unable to raise such capital when needed, or on acceptable terms, we may be forced to delay, reduce or eliminate one or more of our research and drug development programs or future commercialization efforts.

•We are substantially dependent on the success of our lead product candidates, ZN-c3 and ZN-c5, which are currently in clinical trials. If we are unable to complete development of, obtain approval for and commercialize ZN-c3 and/or ZN-c5 in a timely manner, our business will be harmed.

•The outcome of preclinical testing and early clinical trials may not be predictive of the success of later clinical trials, and the results of our clinical trials may not satisfy the requirements of the FDA, EMA or other comparable foreign regulatory authorities.

•We may face additional risks associated with the development of ZN-c3, ZN-c5, ZN-d5, ZN-e4 and potentially other product candidates in combination with other therapies.

•The clinical trial and regulatory approval processes are lengthy, time-consuming and inherently unpredictable, and we may incur additional costs or experience delays in completing, or ultimately be unable to complete, the development and commercialization of our product candidates.

•The competition for qualified personnel is particularly intense in our industry. If we are unable to retain or hire key personnel, then we may not be able to sustain or grow our business.

•We face significant competition and, if our competitors develop and market technologies or products more rapidly than we do or that are more effective, safer or less expensive than the product candidates we develop, our commercial opportunities will be negatively impacted.
ii


•Our success depends on our ability to protect our intellectual property and our proprietary platform. If we are unable to adequately protect our intellectual property and our proprietary platform, or to obtain and maintain issued patents which are sufficient to protect our product candidates, then others could compete against us more directly, which would negatively impact our business.

•Our existing collaborations are important to our business and future licenses may also be important to us and, if we are unable to maintain any of these collaborations, or if these arrangements are not successful, our business could be adversely affected.

•We rely, and expect to continue to rely, on third parties, including independent clinical investigators and CROs, to conduct certain aspects of our preclinical studies and clinical trials. If these third parties do not successfully carry out their contractual duties, comply with applicable regulatory requirements or meet expected deadlines, we may not be able to obtain regulatory approval for or commercialize our product candidates and our business could be substantially harmed.

•Our commercial success depends significantly on our ability to operate without infringing the patents and other proprietary rights of third parties. Claims by third parties that we infringe their proprietary rights may result in liability for damages or prevent or delay our development and commercialization efforts.

•The COVID-19 pandemic has adversely impacted, and we expect will continue to adversely impact, our business, including our preclinical studies and clinical trials.
iii


BASIS OF PRESENTATION
As used in this Quarterly Report on Form 10-Q, unless the context otherwise requires, references to “we,” “us,” “our,” the “Company,” “Zentalis” and similar references refer: (1) following the consummation of our statutory conversion to a Delaware corporation on April 2, 2020 in connection with our initial public offering, to Zentalis Pharmaceuticals, Inc., and (2) prior to the completion of such conversion, to Zentalis Pharmaceuticals, LLC. See “Management’s Discussion and Analysis of Financial Condition and Results of Operations — Corporate Conversion” in this Quarterly Report on Form 10-Q for further information.
iv


PART I—FINANCIAL INFORMATION
3


Item 1. Financial Statements.
Zentalis Pharmaceuticals, Inc.
Condensed Consolidated Balance Sheets
(Unaudited)
(In thousands, except share amounts and par value)
June 30,December 31,
 20212020
ASSETS
Current assets
Cash and cash equivalents$49,170 $54,951 
Marketable securities, available-for-sale201,730 283,554 
Accounts receivable from government grants, net5 417 
Prepaid expenses and other current assets8,301 6,182 
Restricted cash243  
Total current assets259,449 345,104 
Property and equipment, net2,251 1,099 
Operating lease right-of-use assets1,195 2,520 
Prepaid expenses and other assets4,794 2,976 
Deferred financing costs716  
Goodwill3,736 3,736 
In-process research and development8,800 8,800 
Restricted cash3,021 1,320 
Total assets$283,962 $365,555 
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities
Accounts payable$8,273 $8,661 
Accrued expenses25,304 19,940 
Total current liabilities33,577 28,601 
Deferred tax liability2,480 2,480 
Other long-term liabilities296 1,097 
Total liabilities36,353 32,178 
Commitments and contingencies
EQUITY
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued and outstanding at June 30, 2021 and December 31, 2020
  
Common stock, $0.001 par value; 250,000,000 shares authorized; 41,314,864 and 41,040,286 shares issued and outstanding at June 30, 2021 and December 31, 2020, respectively
41 41 
Additional paid-in capital
529,019 509,339 
Accumulated other comprehensive income94 36 
Accumulated deficit(305,309)(200,834)
Total stockholders’ equity223,845 308,582 
Noncontrolling interests23,764 24,795 
Total equity247,609 333,377 
Total liabilities and stockholders’ equity$283,962 $365,555 

See notes to condensed consolidated financial statements.


4


Zentalis Pharmaceuticals, Inc.
Condensed Consolidated Statements of Operations
(Unaudited)
(In thousands, except per share amounts)
 Three Months Ended
June 30,
Six Months Ended
June 30,
 2021 202020212020
Operating Expenses 
Research and development$44,770 $17,452 $83,164 $30,710 
General and administrative10,362 9,924 22,315 13,065 
Total operating expenses55,132 27,376 105,479 43,775 
Operating loss(55,132)(27,376)(105,479)(43,775)
Other Income (Expense)
Investment and other income, net115 84 214 248 
Net loss before income taxes(55,017)(27,292)(105,265)(43,527)
Income tax expense45  241  
Net loss(55,062)(27,292)(105,506)(43,527)
Net loss attributable to noncontrolling interests(488)(435)(1,031)(544)
Net loss attributable to Zentalis $(54,574)$(26,857)$(104,475)$(42,983)
Net loss per common share outstanding, basic and diluted$(1.34)$(0.78)$(2.58)$(2.53)
Common shares used in computing net loss per share, basic and diluted40,738 34,353 40,549 16,978 

See notes to condensed consolidated financial statements.
5


Zentalis Pharmaceuticals, Inc.
Condensed Consolidated Statements of Comprehensive Loss
(Unaudited)
(In thousands)
Three Months Ended
June 30,
Six Months Ended
June 30,
2021202020212020
Net loss(55,062)(27,292)(105,506)(43,527)
Other comprehensive income:
Currency translation effects45  45  
Unrealized gain (loss) on marketable securities(1)4 13 4 
Total comprehensive loss$(55,018)$(27,288)$(105,448)$(43,523)
Comprehensive loss attributable to noncontrolling interests(488)(435)(1,031)(544)
Comprehensive loss attributable to Zentalis$(54,530)$(26,853)$(104,417)$(42,979)

See notes to condensed consolidated financial statements.
6


Zentalis Pharmaceuticals, Inc.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
(in thousands)
 Six Months Ended
June 30,
 20212020
Operating Activities: 
Consolidated net loss(105,506)(43,527)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization198 76 
Share-based compensation19,610 8,010 
Loss on disposal of equipment15  
Amortization of premiums on marketable securities, net521 65 
Changes in operating assets and liabilities:
Accounts receivable412 67 
Prepaid expenses and other assets(3,937)(4,796)
Accounts payable and accrued liabilities4,838 1,212 
Operating lease right-of-use assets and liabilities, net267 (11)
Net cash used in operating activities(83,582)(38,904)
Investing activities:
Purchases of marketable securities(77,812)(137,236)
Proceeds from maturities of marketable securities159,128  
Purchases of property and equipment(1,255)(56)
Net cash provided by/used in investing activities80,061 (137,292)
Financing Activities:
Proceeds from issuance of common stock in initial public offering, net 172,482 
Proceeds from exercise of stock options70  
Contributions from noncontrolling interest owners, net 18,424 
Proceeds from the issuance of Series C convertible preferred units, net 14,228 
Deferred financing costs(386) 
Net cash used in/provided by financing activities(316)205,134 
Net increase/(decrease) in cash, cash equivalents and restricted cash(3,837)28,938 
Cash, cash equivalents and restricted cash at beginning of period56,271 67,489 
Cash, cash equivalents and restricted cash at end of period$52,434 $96,427 
Supplemental disclosure of non-cash investing and financing activities:
Costs incurred in connection with initial public offering included in accounts payable and accrued expenses
$ $70 
Accrued deferred financing costs $330 $ 
The following table provides a reconciliation of cash, cash equivalents and restricted cash reported in the Consolidated Statements of Cash Flows for the periods presented:
7


June 30,
20212020
Cash and cash equivalents$49,170 $96,016 
Restricted cash3,264 411 
Total cash, cash equivalents and restricted cash reported in the Condensed Consolidated Statement of Cash Flows$52,434 $96,427 
See notes to condensed consolidated financial statements.
8


Zentalis Pharmaceuticals, Inc.
Condensed Consolidated Statements of Members’/Stockholders’ Equity(Deficit) and Changes in Redeemable Convertible Preferred Units
(In thousands)

Three Months Ended June 30, 2021
CommonAdditional
Paid-In
Capital
Accumulated Other Comprehensive IncomeAccumulated
Deficit
Noncontrolling
Interests
Total
Equity
SharesAmount
Balance at March 31, 202141,040 $41 $519,030 $50 $(250,735)$24,252 $292,638 
Share-based compensation expense— — 9,919 — — — 9,919 
Other comprehensive income— — — 44 — — 44 
Issuance of common stock in connection with restricted stock unit vesting272 — — — — — — 
Issuance of common stock upon exercise of options, net4 — 70 — — — 70 
Cancellation of restricted stock awards(1)— — — — — — 
Net loss attributable to non-controlling interest— — — — — (488)(488)
Net loss attributable to Zentalis — — — — (54,574)— (54,574)
Balance at June 30, 202141,315 $41 $529,019 $94 $(305,309)$23,764 $247,609 

Six Months Ended June 30, 2021
 CommonAdditional
Paid-In
Capital
Accumulated Other Comprehensive IncomeAccumulated
Deficit
Noncontrolling
Interests
Total
Equity
 SharesAmount
Balance at December 31, 202041,040 $41 $509,339 $36 $(200,834)$24,795 $333,377 
Share-based compensation expense— — 19,610 — — — 19,610 
Other comprehensive income— — — 58 — — 58 
Issuance of common stock in connection with restricted stock unit vesting272 — — — — — — 
Issuance of common stock upon exercise of options, net4 — 70 — — — 70 
Cancellation of restricted stock awards(1)— — — — — — 
Net loss attributable to non-controlling interest— — — — — (1,031)(1,031)
Net loss attributable to Zentalis— — — — (104,475)— (104,475)
Balance at June 30, 202141,315 $41 $529,019 $94 $(305,309)$23,764 $247,609 




9










Three Months Ended June 30, 2020
Zentalis Members/Stockholders
Convertible
Preferred Units
Convertible
Preferred Units
Class A
Common Units
 
Class B
Common Units
Common
Additional Paid-in CapitalAccumulated Other Comprehensive IncomeAccumulated
Deficit
Noncontrolling
Interests
Total
Equity
(Deficit)
UnitsAmountUnitsAmountUnitsAmountUnitsAmountSharesAmount
Balance at March 31, 202010,817 $155,934 — $— 5,601 $709 2,607 $2,507 $ $ $ $ $(99,119)$6,712 $(89,191)
Issuance of common stock in connection with an equity offering, net of underwriting discounts, commissions and offering costs— — — — — — — — 10,589 11 172,354 — — — 172,365 
Contributions from noncontrolling interest owners— — — — — — — — — — — — — 18,424 18,424 
Share-based compensation expense
— — — — — — — — — — 7,681 — — — 7,681 
Conversion of convertible preferred units to common stock(10,817)(155,934)— — — — — — 15,011 15 155,919 — — — 155,934 
Conversion of common and incentive units to common and restricted stock— — — — (5,601)(709)(2,607)(2,507)10,278 10 3,206 — — — — 
Other comprehensive income— — — — — — — — — — — 4 — — 4 
Net loss attributable to non-controlling interest
— — — — — — — — — — — — — (435)(435)
Net loss attributable to Zentalis
— — — — — — — — — — — — (26,857)— (26,857)
Balance at June 30, 2020 $ — $—  $  $ 35,878 $36 $339,160 $4 $(125,976)$24,701 $237,925 







10


Six Months Ended June 30, 2020
Zentalis Members/Stockholders
 Convertible
Preferred Units
Convertible
Preferred Units
Class A
Common Units
Class B
Common Units
CommonAdditional Paid-in CapitalAccumulated Other Comprehensive LossAccumulated
Deficit
Noncontrolling
Interests
Total
Equity
(Deficit)
 UnitsAmountUnitsAmountUnitsAmountUnitsAmountSharesAmount
Balance at December 31, 20199,950 $141,706 — $— 5,601 $709 2,671 $2,178  $   $(82,993)$6,821 $(73,285)
Issuance of Series C convertible preferred units at $17.50 per unit net of issuance costs
867 14,228 — — — — — — — — — — — — — 
Cancellation of profit interest awards, net— — — — — — (64)— — — — — — — — 
Issuance of common stock in connection with an equity offering, net of underwriting discounts, commissions and offering costs— — — — — — — — 10,589 11 172,354 — — — 172,365 
Contributions from noncontrolling interest owners— — — — — — — — — — — — — 18,424 18,424 
Share-based compensation expense
— — — — — — — 329 — — 7,681 — — — 8,010 
Conversion of convertible preferred units to common stock(10,817)(155,934)— — — — — — 15,011 15 155,919 — — — 155,934 
Conversion of common and incentive units to common and restricted stock— — — — (5,601)(709)(2,607)(2,507)10,278 10 3,206 — — — — 
Other comprehensive income— — — — — — — — — — — 4 — — 4 
Net loss attributable to non-controlling interest
— — — — — — — — — — — — — (544)(544)
Net loss attributable to Zentalis
— — — — — — — — — — — — (42,983)— (42,983)
Balance at June 30, 2020 $ — $—  $  $ 35,878 $36 $339,160 $4 $(125,976)$24,701 $237,925 

See notes to condensed consolidated financial statements.
11



NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
1. Organization and Business
Organization
Zentalis Pharmaceuticals, Inc. (“Zentalis”, “We” or the “Company”) is a clinical-stage pharmaceutical company focused on discovering and developing clinically differentiated, novel small molecule therapeutics targeting fundamental biological pathways of cancer. The Company manages its operations as a single segment for the purposes of assessing performance and making operating decisions. All of the Company’s material tangible assets are held in the United States.
The Company was formed and incorporated in the state of Delaware as Zeno Pharmaceuticals, Inc. on December 23, 2014. Effective November 21, 2017, Zeno Pharma, LLC was formed by the shareholders of Zeno Pharmaceuticals, Inc. On December 21, 2017, Zeno Pharmaceuticals, Inc. became a wholly owned subsidiary of Zeno Pharma, LLC. In connection with this restructuring, the rights and preferences of the Preferred Stock of Zeno Pharmaceuticals, Inc. were exchanged for preferred units with similar rights and preferences of Zeno Pharma, LLC. As part of the restructuring, the employees, consultants and board members of Zeno Pharmaceuticals, Inc. exchanged their equity grants in Zeno Pharmaceuticals, Inc. stock for Class B common units in Zeno Pharma, LLC. Additionally, existing common stockholders of Zeno Pharmaceuticals, Inc. exchanged their common stock for Class A common units in Zeno Pharma, LLC. All exchanges were made on a one-for-one basis. The restructuring was accounted for as a common control transaction. In December 2019, the Company was renamed to Zentalis Pharmaceuticals, LLC.
Immediately prior to the effectiveness of the registration statement pertaining to the Company’s initial public offering (“IPO”) on April 2, 2020, the Company converted from a Delaware limited liability company into a Delaware corporation, and changed its name to Zentalis Pharmaceuticals, Inc. Pursuant to the statutory corporate conversion, all of the outstanding units of Zentalis Pharmaceuticals, LLC converted into shares of common stock of Zentalis Pharmaceuticals, Inc. based upon the value of Zentalis Pharmaceuticals, Inc. at the time of the IPO with a value implied by the price of the shares of common stock sold in the IPO. Based on the IPO price of $18.00 per share, the outstanding converted units converted into 25,288,854 shares of common stock (including 1,160,277 shares of restricted common stock).
On April 7, 2020, the Company completed the IPO in which the Company issued and sold 10,557,000 shares of common stock (including 1,377,000 shares of common stock in connection with the full exercise of the underwriters’ option to purchase additional shares) at a public offering price of $18.00 per share. The Company’s aggregate gross proceeds from the sale of shares in the IPO, including the sale of shares pursuant to the full exercise of the underwriters’ option to purchase additional shares, was $190.0 million before fees and expenses of $17.6 million.

Liquidity
Substantial doubt about an entity’s ability to continue as a going concern exists when relevant conditions and events, considered in the aggregate, indicate that it is probable that the entity will be unable to meet its obligations as they become due within one year from the financial statement issuance date. The Company determined that there are no conditions or events that raise substantial doubt about its ability to continue as a going concern within one year after the date that the interim unaudited condensed consolidated financial statements for the quarter ended June 30, 2021 are issued.
12


2. Interim Unaudited Financial Statements
Basis of Presentation
The accompanying interim unaudited condensed consolidated financial statements have been prepared in accordance with United States generally accepted accounting principles (“U.S. GAAP”) and with the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”) related to a quarterly report on Form 10-Q. The year-end condensed consolidated balance sheet data was derived from the Company’s audited financial statements but does not include all disclosures required by U.S. GAAP. These condensed consolidated financial statements and notes thereto should be read in conjunction with the Company’s audited financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on March 25, 2021. The unaudited financial information for the interim periods presented herein reflects all adjustments which, in the opinion of management, are necessary for a fair presentation of the financial condition and results of operation for the periods presented, with such adjustments consisting only of normal recurring adjustments.
The condensed consolidated financial statements include the accounts of our wholly owned subsidiaries, majority-owned or controlled companies, and variable interest entity (“VIE”), Kalyra Pharmaceuticals, Inc. (“Kalyra”), for which we are the primary beneficiary. All intercompany transactions and balances have been eliminated in consolidation.
Use of Estimates
The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in our consolidated financial statements and accompanying notes. On an ongoing basis, we evaluate our estimates and judgments, which are based on historical and anticipated results and trends and on various other assumptions that management believes to be reasonable under the circumstances. By their nature, estimates are subject to an inherent degree of uncertainty and, as such, actual results may differ from management’s estimates.
Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to inform our critical accounting estimates.

Adoption and Pending Adoption of Recent Accounting Pronouncements
The following table provides a brief description of recently issued accounting standards, those adopted in the current period and those not yet adopted:
Standard  Description  Effective Date  Effect on the Financial
Statements or Other
Significant Matters
In January 2020, the FASB issued ASU 2020-01, Investments – Equity Securities (Topic 321)This standard clarifies the interaction between accounting standards related to equity securities (ASC 321), equity method investments (ASC 323), and certain derivatives (ASC 815). January 1, 2021We currently do not hold equity securities, have equity method investments or derivatives. This adoption did not have a material impact on our consolidated financial position or results of operations.
13


3. Business Combinations
Kalyra Pharmaceuticals, Inc.
On December 21, 2017, we acquired $4.5 million of Kalyra’s Series B Preferred Stock representing a 25% equity interest in Kalyra for purposes of entering the analgesics therapeutic research space. The acquisition price was paid entirely in cash.
In accordance with the authoritative guidance, we concluded that Kalyra is a business consisting of inputs, employees, intellectual property and processes capable of producing outputs. Additionally, we have concluded that Kalyra is a variable interest entity, we are the primary beneficiary and have the power to direct the activities that most significantly affect Kalyra’s economic performance through common management and our board representation. Prior to the change of control, the Company and Kalyra transacted for the delivery of research and development services and support. The financial position and results of operations of Kalyra have been included in our consolidated financial statements from the date of the initial investment.
Pursuant with authoritative guidance, we have recorded the identifiable assets, liabilities and noncontrolling interests in the VIE at their fair value upon initial consolidation. The identified goodwill is comprised of the workforce and expected synergies from combining the entities. Total assets and liabilities of Kalyra as of June 30, 2021 and December 31, 2020 are as follows (in thousands):
June 30,December 31,
 20212020
Cash and cash equivalents$663 $417 
Other current assets5 82 
In-process research and development8,800 8,800 
Goodwill3,736 3,736 
Accounts payable and accrued expenses91 83 
Deferred tax liability2,463 2,463 
Noncontrolling interests$6,865 $6,705 
The liabilities recognized as a result of consolidating Kalyra do not represent additional claims on our general assets. Pursuant to the authoritative guidance, the equity interest in Kalyra not owned by Zeno is reported as a noncontrolling interest on our condensed consolidated balance sheets.
The following is a reconciliation of equity (net assets) attributable to the noncontrolling interest (in thousands):
June 30,
 2021
Noncontrolling interest at beginning of period$6,705 
Net income attributable to noncontrolling interest160 
Noncontrolling interest at end of period$6,865 
4. Fair Value Measurement
Available-for-sale marketable securities consisted of the following (in thousands):
14


June 30, 2021
Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
Commercial paper 106,485 22  106,507 
Corporate Debt Securities11,049  (1)11,048 
US Government Agencies53,319 15  53,334 
US Treasury30,828 13  30,841 
201,681 50 (1)201,730 
December 31, 2020
Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value
Commercial paper 147,382 14 (8)147,388 
Corporate Debt Securities23,576 1 (6)23,571 
US Government Agencies81,455 32 (1)81,486 
US Treasury31,105 4  31,109 
283,518 51 (15)283,554 
The Company regularly reviews the securities in an unrealized loss position and evaluates the current expected credit loss by considering factors such as the severity of the impairment, changes in underlying credit ratings, forecasted recovery, our intent to sell or the likelihood that we would be required to sell the investment before its anticipated recovery in market value and the probability that the scheduled cash payments will continue to be made. Based on our review of these marketable securities, we believe none of the unrealized loss is as a result of a credit loss as of June 30, 2021, because we do not intend to sell these securities and it is not more-likely-than-not that we will be required to sell these securities before the recovery of their amortized cost basis.

Contractual maturities of available-for-sale debt securities are as follows (in thousands):
June 30, 2021December 31, 2020
Estimated Fair Value
Due within one year$201,730 $247,455 
After one but within five years 36,099 
$201,730 $283,554 


15


The following table summarizes, by major security type, our cash equivalents and available-for-sale marketable securities that are measured at fair value on a recurring basis and are categorized using the fair value hierarchy (in thousands):
June 30, 2021December 31, 2020
Level 1Level 2Total estimated fair valueLevel 1Level 2Total estimated fair value
Cash equivalents:
   Money market funds$29,346 $ $29,346 $24,016 $ $24,016 
Corporate Debt Securities    4,999 4,999 
Total cash equivalents:29,346  29,346 24,016 4,999 29,015 
Available-for-sale marketable securities:
Commercial paper 106,507 106,507  147,388 147,388 
Corporate Debt Securities 11,048 11,048  23,571 23,571 
US Government Agencies 53,334 53,334  81,486 81,486 
US Treasury securities30,841  30,841 31,109  31,109 
Total available-for-sale marketable securities:30,841 170,889 201,730 31,109 252,445 283,554 
Total assets measured at fair value
$60,187 $170,889 $231,076 $55,125 $257,444 $312,569 

There were no transfers between Level 1 and Level 2 of the fair value hierarchy during the six months ended June 30, 2021. We had no instruments that were classified within Level 3 as of June 30, 2021 or December 31, 2020.
16


5. Prepaid Expenses and Other Assets
Prepaid expenses and other assets consisted of the following (in thousands):
June 30,December 31,
 20212020
Prepaid insurance$2,338 $1,021 
Prepaid software licenses and maintenance385 563 
Foreign R&D credit refund1,148 692 
Prepaid research and development expenses8,100 5,963 
Interest receivable 327 478 
Other prepaid expenses797 441 
Total prepaid expenses and other assets13,095 9,158 
Less long-term portion4,794 2,976 
Total prepaid expenses and other assets, current$8,301 $6,182 
6. Property and Equipment, net
Property and equipment, net consisted of the following (in thousands):
June 30,December 31,
 20212020
Computer and Office Equipment$554 $529 
Lab Equipment1,714 424 
Leasehold Improvements49 49 
Construction in Progress381 347 
Subtotal2,698 1,349 
Accumulated depreciation and amortization(447)(250)
Property and equipment, net$2,251 $1,099